|
KMID : 0620920180500040049
|
|
Experimental & Molecular Medicine
2018 Volume.50 No. 4 p.49 ~ p.49
|
|
|
Protectin DX increases alveolar fluid clearance in rats with lipopolysaccharide-induced acute lung injury
|
|
Zhuo Xiao-Jun
Hao Yu
Cao Fei
Yan Song-Fan
Li Hui
Wang Qian
Cheng Bi-Huan
Ying Bin-Yu
Smith Fang Gao
Jin Sheng-Wei
|
|
|
Abstract
|
|
|
|
Acute respiratory distress syndrome is a life-threatening critical syndrome resulting largely from the accumulation of and the inability to clear pulmonary edema. Protectin DX, an endogenously produced lipid mediator, is believed to exert anti-inflammatory and pro-resolution effects. Protectin DX (5?μg/kg) was injected i.v. 8?h after LPS (14?mg/kg) administration, and alveolar fluid clearance was measured in live rats (n?=?8). In primary rat ATII epithelial cells, protectin DX (3.605?×?10?3?mg/l) was added to the culture medium with LPS for 6?h. Protectin DX improved alveolar fluid clearance (9.65?±?1.60 vs. 15.85?±?1.49, p?
|
|
|
KEYWORD
|
|
|
Acute inflammation, Biological therapy
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
    
|